| publication name | Assessment of Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAM 6) in pancreatic ductal adenocarcinoma (a combined serum and immunohistochemical study) |
|---|---|
| Authors | Mostafa M. Amer (MD)*, Ghada A. Abd El-Fattah (MD)**, Mohebat H. Gouda (MD)**, Rasha M. El-Sawi (MD)**, , Ebada M. Saeed (MD)***, Ahmed Zeedan (MD)****. Department of Clinical Pathology*, Faculty of Medicine, El Azhar University and Departments of Patholo |
| year | 2015 |
| keywords | Chronic pancreatitis (CP), Pancreatic ductal adenocarcinoma (PDAC), Carcinoembryonic antigen-related cell adhesion molecule-6 (CEACAM-6). Chronic pancreatitis (CP), Pancreatic ductal adenocarcinoma (PDAC), Carcinoembryonic antigen-related cell adhesion molecule-6 (CEACAM-6). Chronic pancreatitis (CP), Pancreatic ductal adenocarcinoma (PDAC), Carcinoembryonic antigen-related cell adhesion molecule-6 (CEACAM-6). Chronic pancreatitis (CP), Pancreatic ductal adenocarcinoma (PDAC), Carcinoembryonic antigen-related cell adhesion molecule-6 (CEACAM-6). |
| journal | medical journal of Cairo University |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background: Pancreatic cancer is a disease with an extremely poor prognosis. The acquisition of invasion properties in pancreatic cancer is accompanied by the process of epithelial-mesenchymal transition (EMT). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic cancer. Therefore, the aim of this study was to evaluate the potential involvement of CEACAM6 in the development,invasion and metastasis of pancreatic cancer cells. Patients & Methods: This prospective study includes 7 cases of chronic pancreatitis and 25 cases of pancreatic duct adenocarcinoma, were collected from General Surgery Department, Faculty of Medicine, Benha University and Egyptian National Cancer Institute (NCI), in the period 2010-2014. Carcinoembryonic antigen-related cell adhesion molecule -6 (CEACAM-6) immunohistoc1hemical staining were performed in all cases and the pattern of expression was analyzed. Soluble CEACAM-6was estimated for all cases. Results: Eighty eight percent of pancreatic ductal adenocarcinoma cases were positive to immunohistochemical staining with CEACAM6, while only 14.3% of chronic pancreatitis were positive, which was a statistically significant correlation (p