The worldwide emergence of anthelmintic resistance against gastrointestinal (GIT) parasites prompts investigation towards sustainable alternative approaches. Accordingly, several approaches have been endeavored to control GIT parasites and increase economic values of livestock production systems. Current scientific evidence implies that there is substantial capability to use the plant bioactive compounds to enhance animal’s health and promote their productivity. Despite the great efforts in management, GIT parasites remain the main cause of mortality and weight gain–loss in ruminant industry. Recently, there is worldwide interest in exploiting plants bioactive and their secondary constituents as substitutes to anthelmintic treatment. However, we still necessitate to collect further data about their concentrations, sources, and composition, not only that but also understand their potential beneficial and detrimental …