Objective:To investigate the prevalence and factors associated with superficial tumors in Egyptian water buffalo and cattle and to present their clinical and Immunohistochemical features. Animals:A total of 1253 animals were studied(866-cross breed cattle and 387-native buffalo). Eighty-one cases(64-cattle and 17-buffalo) were suffered from tumor like swelling. The Clinical and microscopical, histopathological and IHC of the tumor were assessed. Additionally, different surgical interferences and anesthesia were applied for their excision. Results:Based on clinical, histopathological and IHC examination, neoplasia were diagnosed in 75 animals(92.59%). Generally, the prevalence rate of tumor was higher in Cattle than buffalo(78.66% vs 21.33%). Animals aged Conclusion and clinical relevance:superficial tumors have high incidence in cattle compared to buffalo. Papilloma, fibroma and dermoid tumor were the most commonly diagnosed benign tumors. SCC, BCC and fibrosarcoma were the most commonly diagnosed malignant tumors. Surgical excision of the superficial tumors offers a satisfy solution. IHC and histopathological examination provides precise techniques for evaluation, and differentiation between benign and malignant tumors.