Staff Members - Benha University
Relationship between sclerostin and coronary tortuosity in postmenopausal femaleswith non-obstructive coronary artery disease
• 2020
Publication Information
Authors
Ismail Mohamed Ibrahim a,⁎,1, El-Sayed Mohamed Farag a,1,
Mohamed Abd El-Shafy Tabl b,1, Mahmoud Abdelaziz
Keywords
Sclerostin
Coronary tortuosity
Tortuosity score
Postmenopausal females
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Coronary tortuosity (CT) is commonly encountered in postmenopausal females and is usually present
without obstructive lesions. Circulating sclerostin levels are elevated in postmenopausal females. In view of
sclerostin's vasculoprotective effect, we aimed to find possible association between circulating sclerostin and CT.
Method: We prospectively enrolled 273 consecutive postmenopausal females with non-obstructive coronary artery
disease diagnosed by coronary angiography. Presence and severity (by tortuosity score) of CT as well as
serum sclerostin levels were assessed for each patient.
Results: Patientswith CT (128, 47% of study group)were significantly older (P650 pg/ml was found to be associatedwith presence of CT (AUC 0.69, 95% CI: 0.61–0.75, P
without obstructive lesions. Circulating sclerostin levels are elevated in postmenopausal females. In view of
sclerostin's vasculoprotective effect, we aimed to find possible association between circulating sclerostin and CT.
Method: We prospectively enrolled 273 consecutive postmenopausal females with non-obstructive coronary artery
disease diagnosed by coronary angiography. Presence and severity (by tortuosity score) of CT as well as
serum sclerostin levels were assessed for each patient.
Results: Patientswith CT (128, 47% of study group)were significantly older (P650 pg/ml was found to be associatedwith presence of CT (AUC 0.69, 95% CI: 0.61–0.75, P