Staff Members - Benha University
High-density lipoprotein cholesterol as a predictor of clinical outcomes in patients achieving low lipoprotein cholesterol targets after elective percutaneous coronary intervention
International Heart and Vascular Disease Journal • 2015
Publication Information
Authors
Tabl M.A.*, Attia A.I., Hamouda M.A., Farag E., Mansour H.A.
Keywords
Coronary intervention, high-density lipoprotein, low-density lipoprotein
Journal
International Heart and Vascular Disease Journal
Publisher
Not Available
Volume
3
Issue
6
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Objective
To investigate the significance of high-density lipoprotein (HDL) cholesterol after statin therapy on the outcomes
of patients with coronary artery disease (CAD) who underwent elective percutaneous coronary intervention (PCI).
Materials and methods
One hundred patients with CAD were included in this prospective study. All patients had elective PCI with their
baseline LDL cholesterol less than 100 mg/dL. Patients were classified according to baseline HDL cholesterol into
two groups: group I with normal HDL cholesterol levels (> 40 mg/dL for men or >50 mg/dL for women) and group
II with low HDL cholesterol levels. Major adverse cardiac events (MACE) were reported in both groups at 6-month
follow-up.
Results
During the follow-up, the low HDL cholesterol group had insignificantly higher rates of composite MACE. HDL cholesterol
levels were inversely related to the occurrence of composite MACE (odds ratio for MACE: 0.3697, 95 % CI:
0.1421 to 0.9619; P=0.0414). Low HDL cholesterol on follow-up was a significant predictor of target vessel revascularization
(TVR) (P=0.009).
Conclusion
Low HDL cholesterol was associated with high MACE after elective PCI and thus clearly influenced the prognosis
To investigate the significance of high-density lipoprotein (HDL) cholesterol after statin therapy on the outcomes
of patients with coronary artery disease (CAD) who underwent elective percutaneous coronary intervention (PCI).
Materials and methods
One hundred patients with CAD were included in this prospective study. All patients had elective PCI with their
baseline LDL cholesterol less than 100 mg/dL. Patients were classified according to baseline HDL cholesterol into
two groups: group I with normal HDL cholesterol levels (> 40 mg/dL for men or >50 mg/dL for women) and group
II with low HDL cholesterol levels. Major adverse cardiac events (MACE) were reported in both groups at 6-month
follow-up.
Results
During the follow-up, the low HDL cholesterol group had insignificantly higher rates of composite MACE. HDL cholesterol
levels were inversely related to the occurrence of composite MACE (odds ratio for MACE: 0.3697, 95 % CI:
0.1421 to 0.9619; P=0.0414). Low HDL cholesterol on follow-up was a significant predictor of target vessel revascularization
(TVR) (P=0.009).
Conclusion
Low HDL cholesterol was associated with high MACE after elective PCI and thus clearly influenced the prognosis