Staff Members - Benha University
Assessment of Intermediate Coronary Artery Lesion with Fractional Flow Reserve (FFR) versus Intravascular Ultrasound (IVUS)
International Journal of Cardiology and Cardiovascular Research • 2015
Publication Information
Authors
Mohamed A. Tabl1, Osama Sanad1, Hisham Abo Elanin1, Hazim Khamis2, Wail Tawfik1
Keywords
Fractional Flow Reserve, Intravascular Ultrasonography, Intermediate stenosis
Journal
International Journal of Cardiology and Cardiovascular Research
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Fraction flow reserve (FFR) is considered the gold standard for assessing intermediate coronary lesions. Retrospective data analyses showed variable relationship between intravascular ultrasound (IVUS) parameters and FFR results. This study aimed to determine the optimal minimum lumen area (MLA) by IVUS that correlates with FFR and to assess the correlation between two modalities in assessing intermediate coronary lesions. Methods: Fifty eight intermediate coronary lesions mainly located in proximal and mid segments of large main coronary vessels with reference vessel diameter (RVD) between 3-4mm were analyzed using both IVUS and FFR to assess the significance of coronary stenting and to determine the optimal IVUS-MLA that correlates with FFR value < 0.8. Results: IVUS-MLA ranged from 2.5 to 4.2 mm2 had a highly significant positive correlation with FFR value < 0.8 (p < 0.0001). Using the ROC curve analysis, IVUS-MLA < 3.9 mm2 (84.2% sensitivity, 80% specificity, area under curve (AUC) = 0.68) was the best threshold value for identifying FFR