Staff Members - Benha University
Synthetic Methods of 1H-Pyrazolo[1,2- b]Phthalazine Derivatives
Current Organic Chemistry • 2022
Publication Information
Authors
Rizk E. Khidre, Mohamed S. Mostafa
2
, Yousef E. Mukhrish
, Mounir A. Salem
and Mohamed S. Behalo
Keywords
Pyrazole, phthalazine, multi-component reactions, heterocycles, pharmacological activities, synthetic methods
Journal
Current Organic Chemistry
Publisher
Bentham Science
Volume
26
Issue
22
Pages
2055-2069
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Abstract: This review deals with the synthetic methods of pyrazolo[1,2-
b]phthalazine derivatives using one-pot multi-component reactions via modern and traditional methods. The synthetic methods are subdivided into groups according to the type of reactants e.g. (1) one-pot
three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and acetonitriles; (2)
one-pot three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and aroyl
acetonitriles; (3) one-pot three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and acetylacetone or 4-hydroxy-2H-chromen-2-one or acetylene derivatives; (4) one-pot
four-component condensation reaction of phthalimide, hydrazine hydrate, aldehydes and acetonitriles; (5) one-pot four-component reaction of phthalic acid, hydrazine hydrate, indole-3-
carbaldehyde and acetonitriles; and (6) one-pot three-component condensation reaction of 2,3-
dihydrophthalazine-1,4-dione, aldehyde, and dimedone derivatives. Moreover, the various methods were reported.
b]phthalazine derivatives using one-pot multi-component reactions via modern and traditional methods. The synthetic methods are subdivided into groups according to the type of reactants e.g. (1) one-pot
three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and acetonitriles; (2)
one-pot three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and aroyl
acetonitriles; (3) one-pot three-component reaction of 2,3-dihydrophthalazine-1,4-dione, aldehydes and acetylacetone or 4-hydroxy-2H-chromen-2-one or acetylene derivatives; (4) one-pot
four-component condensation reaction of phthalimide, hydrazine hydrate, aldehydes and acetonitriles; (5) one-pot four-component reaction of phthalic acid, hydrazine hydrate, indole-3-
carbaldehyde and acetonitriles; and (6) one-pot three-component condensation reaction of 2,3-
dihydrophthalazine-1,4-dione, aldehyde, and dimedone derivatives. Moreover, the various methods were reported.