Staff Members - Benha University
Green synthesis of 1,3,4-oxadiazole derivatives based on N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin- 2(1H)-yl)acetohydrazide as potential antitumor agents
journal of heterocyclic chemistry • 2021
Publication Information
Authors
Mohamed S. Behalo | Ebtsam S. El Said
Keywords
1,3,4-oxadiazoleو antitumor agents
Journal
journal of heterocyclic chemistry
Publisher
Not Available
Volume
57
Issue
1
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Mohamed Sayed Abd el-Rhman Sayed Behalo_New Microsoft Word Document.docx
Abstract
Design of a new series of 1,3,4-oxadiazole derivatives was achieved in good yield
via treatment of N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2(1H)-yl)
acetohydrazide with cerium (IV) ammonium nitrate as a catalyst. They can be formulated also using one-pot reaction of 2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2
(1H)-yl)acetohydrazide, aromatic aldehyde and cerium (IV) ammonium nitrate in
dichloromethane. The structural formulas of all synthesized products were elucidated based on their elemental and spectral analyses. In addition, MTT assay was
used to evaluate antitumor activity of the synthesized molecules and some of them
showed potent activity in comparison with Doxorubicin as a standard drug.
via treatment of N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2(1H)-yl)
acetohydrazide with cerium (IV) ammonium nitrate as a catalyst. They can be formulated also using one-pot reaction of 2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2
(1H)-yl)acetohydrazide, aromatic aldehyde and cerium (IV) ammonium nitrate in
dichloromethane. The structural formulas of all synthesized products were elucidated based on their elemental and spectral analyses. In addition, MTT assay was
used to evaluate antitumor activity of the synthesized molecules and some of them
showed potent activity in comparison with Doxorubicin as a standard drug.