Staff Members - Benha University
Cardanol-based green nanovesicles with antioxidant and cytotoxic activities
JOURNAL OF EXPERIMENTAL NANOSCIENCE, • 2016
Publication Information
Authors
Mohamed Sayed Behalo, Ermelinda Bloise, Luigi Carbone, Roberta Del Sole,
Diego Lomonaco, Selma Elaine Mazzetto, Giuseppe Mele & Lucia Mergola
Keywords
cardanol; green
nanovescicles; phthalazines;
bioactive nanosystems
Journal
JOURNAL OF EXPERIMENTAL NANOSCIENCE,
Publisher
Taylor & Francis
Volume
12
Issue
Not Available
Pages
1274-1284
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
This manuscript describes the preparation of green nanovesicles by using cardanol as renewable starting material with embedded minor amounts of phthalazines, a class of heterocyclic bioactive compounds. The nanovesicles were prepared by stirring induced
self-assembly in aqueous medium without involvement of any organic solvent. Dynamic light scattering studies and transmission electron microscopy revealed the formation of nanostructure with an average diameter in the range of 227375 nm and a well defined spherical morphology. Potential antioxidant activity of nanovesicles were evaluated for the first time by 2,20-azino-bis-(3-
ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging assay and bleomycin-dependent DNA damage. Moreover, their cytotoxic effects were also investigated by 3-[4,5-dimethylthiazole-2-yl]-2,5- diphenyltetrazolium bromide (MTT) assay on different tumour cell
lines. Unloaded nanovesicles showed moderate antioxidant and antitumoural activity that was further enhanced particularly by embedding the 2-[4-(4-Hydrazinophthalazin-1-yl)-phenyl]-isoindole-
1,3-dione compound.
self-assembly in aqueous medium without involvement of any organic solvent. Dynamic light scattering studies and transmission electron microscopy revealed the formation of nanostructure with an average diameter in the range of 227375 nm and a well defined spherical morphology. Potential antioxidant activity of nanovesicles were evaluated for the first time by 2,20-azino-bis-(3-
ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging assay and bleomycin-dependent DNA damage. Moreover, their cytotoxic effects were also investigated by 3-[4,5-dimethylthiazole-2-yl]-2,5- diphenyltetrazolium bromide (MTT) assay on different tumour cell
lines. Unloaded nanovesicles showed moderate antioxidant and antitumoural activity that was further enhanced particularly by embedding the 2-[4-(4-Hydrazinophthalazin-1-yl)-phenyl]-isoindole-
1,3-dione compound.