Staff Members - Benha University
Synthesis and Evaluation of Pyrido[2,3-d]pyrimidine and 1,8-Naphthyridine Derivatives as Potential Antitumor Agents
J. Heterocyclic Chem • 2017
Publication Information
Authors
Mohamed S. Behalo* and Giuseppe Mele
Keywords
Not Available
Journal
J. Heterocyclic Chem
Publisher
Wiley
Volume
54
Issue
Not Available
Pages
295
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Abstract
New series of pyrido[2,3-d]pyrimidine and 1,8-naphthyridine derivatives were synthesized from 2-amino-6-(phenoxathiin-2-yl)-4-(thiophene-2-yl) nicotinonitrile as starting material, and their structures were characterized
on the basis of the spectral data. Most of the synthesized compounds were evaluated for their cytotoxic activity against two cancer cell lines, namely, breast cancer Michigan Cancer Foundation-7 (MCF-7) and prostate cancer human prostatic carcinoma cell line (PC-3) using MTT assay. Some of these compounds showed potent cytotoxic effect concluded from their IC50 values.
New series of pyrido[2,3-d]pyrimidine and 1,8-naphthyridine derivatives were synthesized from 2-amino-6-(phenoxathiin-2-yl)-4-(thiophene-2-yl) nicotinonitrile as starting material, and their structures were characterized
on the basis of the spectral data. Most of the synthesized compounds were evaluated for their cytotoxic activity against two cancer cell lines, namely, breast cancer Michigan Cancer Foundation-7 (MCF-7) and prostate cancer human prostatic carcinoma cell line (PC-3) using MTT assay. Some of these compounds showed potent cytotoxic effect concluded from their IC50 values.