| publication name | PLASMA ENDOTHELIN- I LEVEL IN CIRRHOTIC PATIENTS WITH AND WITHOUT HEPATORENAL SYNDROME |
|---|---|
| Authors | InasEL-ShaarawyMD*,AbdelBasetM.Z.MD**andMohamedShawkyMD*** |
| year | 1998 |
| keywords | |
| journal | |
| volume | Vol. 15 N01Ja11. 1998 |
| issue | Not Available |
| pages | 29-41 |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Thisstudywasconductedon12cirrhoticnon—asciticpatients,10cirrhotic asciticpatients withpreservedkidneyfunction, 15cirrhoticpatients withhepatorenalsyndrome(was)aswellas 10well— matched healthyvolunteersservingascontrob. Theaimofthisworkwastostudyplasmaendothelin-l{ET-I)levelin livercirrhosisandtoshedlightoni.tspossibleroleinthepathogenesisof HRS. Thefollowinginvestigationswereperformedtoeverysubjectbiochemicalliverfunctiontests,senirncreatinine,urinecreatinine,serumNa+,24 hoursurineNa+andplasmaET-llevel. DiagnosisofHRSwasmadewhenserumcreatinineishighandfraclionexcretionofthefilteredsodiumislessthanI . PlasmaET—1 level wassignificantly elevated in allpatientgroups whencomparedwithcontrols. However,plasmaET-llevelwassignificantly higherin cirrhotic ascitic1patients thancirrhotic non-asciticpatients.PatientswithHRSexhibitedthehighestplasmaET-llevelPlasma ET-Ishowedsignificantnegativecorrelationwithserumalbumin,serum &urinaryNa+,whereasitshowedsignificantpositivecorrelation with seru.mtransarninases.alkalinephosphatase,serumbilirubinandserum creatinine: