Objecu've: This study was done to detect the serum level of soluble L-selectin (sL-selectin) and plasma level of jlbronectin (pFN) in patients with rheumatoid arthritts~ (RA) and compare these levels to normal healthy controls. The aim extends to determine the relation of these levels to cl.micalparameters of disease activity. Methodology: Fifty patients with RA as well as twenty healthy persons- as a control group- were included into this study. All patients were subjected to full clinical assessment and laboratory investigations. sL-selectin and pFN were measured in patients and controls using the enZyme-linked immunosorbent assay technique, and their correlations with disease activity parameters were studied. Results: Serum levels of sL-selectin and pFN were highly significantly increased in RA patients as compared to healthy controls (p