Background: . End stage renal disease ( ESRD) is now considered a prototypical situation of chronic inflammatory state . Inflammation is thought to contribute to initiation and aggravation of atherosclerosis through a process predominantly mediated by adhesion molecules. The expression of soluble Intercellular cell adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1 )on the cell surface is upregulated by inflammation.The aims of this study were to measure sICAM-1 and sVCAM-1 in sera of normotensive and hypertensive CRF patients under hemodialysis (HD) and compare them with healthy controls. Also, the effect of dialyzer on these molecules was studied in a single uncomplicated HD session. Methods: We evaluated 40 patients with CRF under treatment with regular HD , they were classified into two groups : Group I : 20 hypertensive patients (12 males and 8 females)aged 30±8.2 years, Group II : 20 normotensive patients (11 males and 9 females)aged 34.0±16.8 years ,Ten healthy volunteers constituted group III ( 5 males and 5 females ), aged 33.0±10.2 years . Blood samples were taken from all patients 4 times , at start and at the end of HD session and from the inlet and exit lines of the dialyzer , 5ml of blood were collected from controls. sICAM-1 and sVCAM-1 were measured by ELISA .