Staff Members - Benha University
STUDY OF PLASMA OSTEOPONTIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS WITH AND WITHOUT EVIDENCE OF LUNG FIBROSIS
The Egyptuan Jornal of Chest diseases and tuberculosis • 2008
Publication Information
Authors
Mahmood Alsalahy*MD, Mohammad Hassan**MD, Refaat Altanawy***MD and Anas Yosof**** MD and Mohamed I Abdelfattah MD *****
Keywords
SLE , RA,Osteopontin
Journal
The Egyptuan Jornal of Chest diseases and tuberculosis
Publisher
Not Available
Volume
57
Issue
1,2
Pages
121-127
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
To study the relation of the newly discovered proinflammatory cytokine osteopontin (OPN) to lung fibrosis in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), we selected 18 RA patients ( 7 ♂ and 11♀; 29.28 ± 10.42 years ) and 17 (6 ♂and 11♀, 37.7 ± 7.11 years) and 10 normal controls ( 27.3 ± 9.01 years). 7 of RA and 6 of SLE patients have clinical and radiological evidence of lung fibrosis. FEV1 % predicted, ESR, serum CRP and plasma osteopontin were measured. FEV1 % predicted was significantly lower in patients than controls and in those with fibrosis than in those without in both groups (p< 0.001 and