| publication name | STUDY OF PLASMA OSTEOPONTIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS WITH AND WITHOUT EVIDENCE OF LUNG FIBROSIS |
|---|---|
| Authors | Mahmood Alsalahy*MD, Mohammad Hassan**MD, Refaat Altanawy***MD and Anas Yosof**** MD and Mohamed I Abdelfattah MD ***** |
| year | 2008 |
| keywords | SLE , RA,Osteopontin |
| journal | The Egyptuan Jornal of Chest diseases and tuberculosis |
| volume | 57 |
| issue | 1,2 |
| pages | 121-127 |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
To study the relation of the newly discovered proinflammatory cytokine osteopontin (OPN) to lung fibrosis in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), we selected 18 RA patients ( 7 ♂ and 11♀; 29.28 ± 10.42 years ) and 17 (6 ♂and 11♀, 37.7 ± 7.11 years) and 10 normal controls ( 27.3 ± 9.01 years). 7 of RA and 6 of SLE patients have clinical and radiological evidence of lung fibrosis. FEV1 % predicted, ESR, serum CRP and plasma osteopontin were measured. FEV1 % predicted was significantly lower in patients than controls and in those with fibrosis than in those without in both groups (p< 0.001 and