We examined the variations in eating behavior, appetite ratings, satiety efficiency, energy expenditure, anthropometric andmetabolic profile markers prior to, during as well as 1 and 4 months after Ramadan in normal-weight and obese men.Anthropometric, energy expenditure (indirect calorimetry and accelerometry), metabolic (fasting blood sample), appetite (visualanalogue scales), and eating behavior (Three-Factor Eating Questionnaire) measurements were performed in 10 normal-weight(age: 25.2±4.7 years; BMI: 24.4±1.9 kg/m2) and 10 obese (age: 27.0±4.5 years; BMI: 34.8±3.7 kg/m2) men. The satiety quotient(SQ) was calculated 180 minutes after breakfast consumption. All anthropometric variables, as well as resting and total energyexpenditure, were greater in obese compared to normal-weight participants (P= 0.02–0.0001). Similarly, obese participantshad greater triglycerides, insulin, and homeostatic model assessment-insulin resistance concentrations (P= 0.02–0.002). Greaterapolipoprotein B, glucose, total cholesterol, and low-density lipoprotein concentrations were noted during Ramadan (P= 0.04–0.0001). Dietary restraint scores were also greater during Ramadan (푃=0.0001). No differences in anthropometry, other metabolicprofile markers, energy expenditure, appetite ratings, and SQ were noted across sessions. Lastly, changes in anthropometricmeasurements correlated with delta metabolic profile markers, as well as changes in disinhibition eating behavior trait and dietaryrestraint scores. The Ramadan fast led to increases in certain metabolic profile markers despite no changes in appetite andanthropometry.