Background: Vitiligo is a multifactorial polygenic disorder commonly associated with other autoimmune diseases. The reported link between vitiligo and abnormalities of serum interleukin (IL) -17, zinc, calcium, and vitamin D is not fully understood. Objectives: To assess serum level of vitamin D, calcium, zinc, and IL-17 in vitiligo patients, and to answer the question if vitiligo patients are more prone to myocardial infarction. Design: The participants enrolled in this case-control study and we did not exclude any participant with another systemic autoimmune disease. Serum vitamin D, calcium, zinc, and IL-17 measured and correlated to disease severity. Setting: The study was carried out in Benha University hospitals in Egypt. Participants: Thirty vitiligo patients and thirty age and sex-matched healthy volunteers included. Measurements: The diseases severity measured by Vitiligo Extent Tensity Index (VETI) score. Results: Vitiligo patients showed a significantly lower level of vitamin D (P