Background: We are trying to detect the optimum approach for appendectomy in morbidly obese patients by evaluating laparoscopic appendectomy (LA) and open appendectomy (OA) techniques applied in this group of patients. Material and Methods: The records of 314 patients who underwent appendecto-my for acute appendicitis between Au-gust 2016 and August 2018 were ana-lyzed retrospectively. Exclusion criteria were: those under 18 years, body mass index (BMI) 40 kg/m2, and those with a perforation and/or appendicular mass. The remaining 105 patients were in-volved in the study. The patients were classified into 2 groups: group A, in-cludes 50 patients underwent LA and group B, includes 55 patients underwent OA. Socio-demographic data, operative time, surgery-related superficial surgical site infection (sSSI), intra-abdominal complication, non-surgical complication, and length of postoperative hospital stay were recorded. Results: No statistically significant vari-ations was detected between LA and OA groups in terms of age and gender (P=0.51, P=0.69 respectively). However, the average BMI value in the LA group was found to be significantly higher (P