Background: Recurrence of cancer breast is a major problem during
the first 2 years after diagnosis in addition to selection of adjuvant
regimen is based mainly on the axillary lymph nodes stage. So, cost- effectively, patient will save much amount of budget needed for
detection of gene expression. This study evaluates axillary lymph
nodes dissection in prognosis of HER2-positive breast cancer. Patients and methods: The current study analyzed 100 patients
complained breast cancer. There were two types of surgery performed;
MRM in 46 cases (46%) when there were contraindications of BCT or
patients preferred radical surgery and BCT in 54 cases (54%) when
indicated. Follow-up was for 2 years. Results: All cases passed operation without mortality. Recurrence was
reported in ten patients (10%). Six patients (6%) died during their
follow up due to distant metastasis. All recurrent patients having grade
N3 >9 positive lymph nodes; P-value; 0.0001. There was statistical
significance between nodal status and tumor size; KW test & P; 8.08 &
0.044 (S) respectively and between Histopathology and Nodal status;
FET & P; 5.96 & 0.031 (S) respectively. Conclusion: Positive or negative axillary lymph nodes are considered
the most important predicting factor for recurrence and overall survival
of HER2-positive patients complained breast cancer. Moreover
worsening prognosis is closely related to which group positive and the
number of affected lymph nodes.