This study was conducted on adult and calf buffaloes for recording the clinico-hematobiochemical alteration of parasitic enteritis. Diarrheic buffaloes showed depression, dullness, depraved appetite, variable degree of diarrhea, cessation of rumination, labored breathing, accelerated heart and respiratory rates, weakness and a reluctance to move. As diarrhea progressed, dehydration of the affected buffalo was evidence with signs of alopecia. Hematological analysis showed significant decrease in RBCs, Hb, PCV and WBCs. Serum biochemical analysis revealed significant decrease in sodium, chloride, copper, zinc and iron glucose and SOD levels in diarrheic buffaloes. While, there was significant increase in serum potassium and haptoglobin levels in diarrheic buffaloes compared with control. Therefore, we concluded the parasitic enteritis was associated with alteration in hematology and serum micronutrient as well as the oxidative stress indicated by lowered SOD.