The aim of this work was to utilize the metabolic profile test (MPT) for evaluation of the changes in Friesian cows (n=25) during the peri-parturient period in association with body condition score (BCS) using multiparous postpartum cow (n=20) and heifers (n=5). The clinical signs included anemia during the pre-parturient period, and hypocalcaemia and ketosis during the post-parturient period. RBCs count, hemoglobin concentration, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration significantly (P<0.05) decreased during peri-parturient period as compared to heifers. WBCs count considerably (P<0.05) decreased during pre-parturient period while lymphocytes count showed a significant increase (P<0.05) during peri-parturient period. On the other hand, neutrophils count showed a significant decrease (P<0.05) during peri-parturient period. Glucose significantly (P<0.05) increased during 2-3 weeks pre-partum, non-esterified fatty acids, beta hydroxyl butyric acid, triglycerides, cholesterol, low density lipoprotein, very low density lipoprotein, alanine amino transferase, gamma glutamyl transferase, urea and creatinine clearly (P<0.05) increased during peri-parturient period, insulin. Total protein and lecithin cholesterol acyltransferase significantly decreased during 2-3 weeks pre-partum, whereas serum cortisol, aspartate amino transferase enzyme obviously (P<0.05) increased as parturition approach. High density lipoprotein and globulin significantly (P<0.05) decrease during peri-parturient period. Besides, There was a significant (P<0.05) decrease in Ca, P, Mg, K and Na concentrations during the peri-parturient period. BCS of Friesian cows showed a significant decrease (P<0.05) during postpartum period. It was concluded that MPT is a reliable method for recording the hematological and biochemical changes as well as determination of liver and kidney function status during the peri-partureint period in cattle. Under field condition, body condition score is considered a supplementary aid for MPT for determination of the susceptibility of peri-parturient cows for subclinical or clinical metabolic or nutritional deficiency disorders. KEY WORDS: Body condition score, metabolic diseases, metabolic profile test, LCAT.