Staff Members - Benha University
Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet
Diabetologia • 2018
Publication Information
Authors
Jian Li, Yong-Ping Lu, Oleg Tsuprykov, Ahmed A. Hasan, Christoph Reichetzeder, Mei Tian, Xiao Li Zhang, Qin Zhang, Guo-Ying Sun, Jingli Guo, Mohamed M. S. Gaballa, Xiao-Ning Peng, Ge Lin & Berthold Hocher
Keywords
Glucose tolerance; High-fat-sucrose-salt diet; Maternal folate treatment; Paternal programming
Journal
Diabetologia
Publisher
Springer
Volume
61
Issue
8
Pages
1862–1876
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
AIMS/HYPOTHESIS:
Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy.
METHODS:
Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams. After mating, the F0 dams were fed control diet with or without folate during pregnancy.
RESULTS:
Male, but not female offspring of HFSSD-fed founders were heavier than those of control-diet-fed counterparts (p
Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy.
METHODS:
Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams. After mating, the F0 dams were fed control diet with or without folate during pregnancy.
RESULTS:
Male, but not female offspring of HFSSD-fed founders were heavier than those of control-diet-fed counterparts (p