Abstract Objectives: this study aimed to investigate the relation between the C-reactive protein (CRP) levels and atopic and non-atopic Asthma in children. Patients & Methods: the study included 20 healthy children (mean age 9.2 ±2.1 years) and 66 pediatric patients with asthma during the attack, atopic (n=30) and non-atopic (n=36), mean age `9.7±2.1 and 7.5±1.7 years respectively. CRP level was estimated to all children. Results: serum CRP levels were significantly increased in patients with non-atopic asthma (39.2±19.8 mg/dl) compared with patients with atopic asthma (7.6± 4.1 mg/dl) and controls (5.2±2.1 mg/dl), with no significant difference between the later 2 groups. Conclusion: Raised levels of CRP are significantly with non-oatopic asthma but not with atopic asthma in children. The increased CRP levels in non-atopic asthma support the theory that, in non-atopic asthma, there is not only a local but also an ongoing systemic inflammatory process.