Staff Members - Benha University
Impact of letrozole on ultrasonographic markers of endometrial receptivity in polycystic ovary syndrome women with poor endometrial response to clomiphene citrate despite adequate ovulation
• 2015
Publication Information
Authors
Ahmed Walid A. Morad *, Mohamed A. Elhadi Farag
Keywords
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publication.type
International
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Abstract
Objectives: To investigate the endometrial effects of letrozole in PCOS women with
poor endometrial response (endometrium thickness 67 mm) to clomiphene citrate (CC) despite adequate
ovulation, using the ultrasonographic markers of endometrial receptivity.
Study design: Ambidirectional cohort study.
Patients and methods: Sixty women with anovulatory PCOS having endometrial thickness less
than 7 mm despite adequate ovulation with CC underwent ovulation induction with Letrozole
(5 mg/day from cycle day 3 to 7) for one treatment cycle. Main outcome measures: Comparison
of the endometrial thickness (ET) and pattern, uterine artery and spiral artery, resistance index
(RI) and pulsatility index (PI) between the current letrozole and previous CC stimulated cycles.
Results: In the current letrozole cycle compared with the previous CC cycles, there were significantly
greater midcycle endometrial thickness (8.97 ± 1.32 vs. 5.7± 1.2, respectively; P < 0.05),
multilayered endometrial pattern (93.33% vs. 50%, respectively; P
poor endometrial response (endometrium thickness 67 mm) to clomiphene citrate (CC) despite adequate
ovulation, using the ultrasonographic markers of endometrial receptivity.
Study design: Ambidirectional cohort study.
Patients and methods: Sixty women with anovulatory PCOS having endometrial thickness less
than 7 mm despite adequate ovulation with CC underwent ovulation induction with Letrozole
(5 mg/day from cycle day 3 to 7) for one treatment cycle. Main outcome measures: Comparison
of the endometrial thickness (ET) and pattern, uterine artery and spiral artery, resistance index
(RI) and pulsatility index (PI) between the current letrozole and previous CC stimulated cycles.
Results: In the current letrozole cycle compared with the previous CC cycles, there were significantly
greater midcycle endometrial thickness (8.97 ± 1.32 vs. 5.7± 1.2, respectively; P < 0.05),
multilayered endometrial pattern (93.33% vs. 50%, respectively; P