The most obvious metabolic abnormality in obese children is the acquired resistance to the action of insulin on glucose utilization in both fat and muscle cel/s. This is associated with hyperinsulinemia, especially in those with central obesity. This study was designed in so as to evaluate serum insulin and C-peptide levels in children with simple obesity. 40 children with simple obesity (22 males and 18 females; aged 7-14 years; mean :::= 7.6 ± 1.1 yr) as well as 20 apparently healthy and normal weight controls were enrolled. According to weight for height ratio and body mass index (BMI), the obese children were classified into two groups: group I which included 20 superobese children and group II which included 20 obese children. All studied children were subjected to clinical examination, anthropometric measurements and a comprehensive battery of investigations encompassing blood sugar, serum lipids profile [total cholesterol, total triglyeerides (TG), low-density lipoprotein cholesterol (U)L·C), and high-density lipoprotein cholesterol (HDL-C)], serum C-peptide as well as serum insulin. The t"esults of the present study showed that blood sugar levels, total cholestel"ol serum levels, TG serum levels and LDL-C serum levels were significantly highet" and HDL-C was signif1cantly lower in obese children than in controls ([>