Objectives: To evaluate the outcome of single-setting laparoscopic sleeve gastrectomy (LSG) and uvulopalatopharyngeoplasty (UPPP) as a management policy for Obesity-associated sleep-disordered breathing. Patients & Methods: The study included 23 obstructive sleep apnea syndrome (OSAS) with body mass index (BMI) >40 kg/m2. Preoperative OSAS evaluation included Epworth Sleepiness Scale (ESS) and polysomnography to determine the apnea-hypopnea index (AHI). OSAS was diagnosed if the patients demonstrated an AHI ≥15/h or ≥5/h with an ESS ≥10. Body weight (BW) and BMI were evaluated at 1, 3 and 6 months after surgery and the percentage of excess weight loss (%EWL) and the percentage of excess BMI loss (%EBMIL). AHI and ESS score were re-determined at 6 months after surgery and percentage of change was determined. Results: Mean total theatre time was 105.3±10.7, mean time till first ambulation was 2.5±0.7 hours, mean time for first oral intake was 41±11.2 hours and mean hospital stay was 4.9±0.8 days. LSG and postoperative dieting regimen allowed significant progressive BW reduction with a progressive increase of %EWL and %EBMIL at 6 months after surgery compared to percentages reported at 3 months after surgery. Moreover, BMI strata showed progressive change with 21 women had BMI 35 but