Background: Jones fracture of the base fifth metatarsal is one of the most common foot injuries. Delayed union, nonunion and, refracture are all known complications that can occur, and operative intervention then must be considered. Methodology: Seventy-five patients who had recent Jones fractures were treated surgically by intramedullary cannulated screws. Age of the patients ranged from 18 to 40 yr with an average age of 26.4 yr. There were 51 male patients and 24 female patients. Results: All fractures were united within 6 to 12wk, with an average of 7.2wk. According to American Orthopaedic Foot and Ankle Society (AOFAS) score, final scores ranged from 95 to 98 points with an average of 97.5 points. An irritant screw that needed to be removed after fracture union was encountered in two patients. Conclusions: The use of primary intramedullary screws is a safe and effective option for patients who have Jones fractures, especially those who need early ambulation and excellent osseous union rates.