Staff Members - Benha University
Comparison of cabergoline versus calcium infusion in ovarian hyperstimulation syndrome prevention: A randomized clinical trial
• 2018
Publication Information
Authors
Mohamed Anwar Elnory, Ashraf Nassif Mahmoud Elmantwe ⇑
Keywords
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publication.type
International
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Abstract
Aim: To compare effectiveness of calcium infusion (CI) versus oral cabergoline (OC) in lowering the incidence
and severity of ovarian hyperstimulation syndrome (OHSS) in high risk women undergoing
in vitro-fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Patients and methods: This trial was conducted at Benha University Hospital and Hawaa specialized infertility
center, including 230 women undergoing ICSI, 115 women received intravenous Calcium gluconate
starting at ovum pick up (OPU) day and 115 women received OC 0.5 mg starting at the day of OPU outcomes
were the overall incidence of OHSS as well as its type and severity, in addition to others pregnancy
outcomes data.
Results: The occurrence of overall OHSS was significantly lower in calcium infusion group (CIG) than in
oral cabergoline group (OCG) [16/115 (13.9%) in CIG versus 32/115 (27.8%)] in OCG with difference in
proportion percentage point (D pp) = 13.9% , at 95%CI of 3.38% to 24.10% (P = 0.009) and absolute
risk reduction (ARR) in overall OHSS incidence = 13.9% at 95%CI of 3.38–24.10 and relative risk (RR) =
0.5 at 95% CI of 0.29–0.85 (p = 0.012) and relative risk reduction (RRR) = 50% and number need to treatment
(NNT) (Benefit) = 7.18 at 95% CI of 4.12 (Benefit) to 28.05 (Benefit)]. Also the incidence of Moderate
OHSS was significantly lower in CIG than OCG [2/115 (1.7 %) vs 10/115 (8.6%), p = 0.01] as well as RR of
severe OHSS with CI to OC = 0.25 at 95%CI of 0.02–2.20 and RRR of severe OHSS with CI to OC was 75% as
it occurred in 4 cases (3.4%) in OCG versus one case (0.8%) in CIG, where this reduction is of great clinical
significant despite it does not reach statistical significance (P = 0.17), at NNT (Benefit) = 38.33 at 95% CI of
87.292 (Harm) to 1
and severity of ovarian hyperstimulation syndrome (OHSS) in high risk women undergoing
in vitro-fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Patients and methods: This trial was conducted at Benha University Hospital and Hawaa specialized infertility
center, including 230 women undergoing ICSI, 115 women received intravenous Calcium gluconate
starting at ovum pick up (OPU) day and 115 women received OC 0.5 mg starting at the day of OPU outcomes
were the overall incidence of OHSS as well as its type and severity, in addition to others pregnancy
outcomes data.
Results: The occurrence of overall OHSS was significantly lower in calcium infusion group (CIG) than in
oral cabergoline group (OCG) [16/115 (13.9%) in CIG versus 32/115 (27.8%)] in OCG with difference in
proportion percentage point (D pp) = 13.9% , at 95%CI of 3.38% to 24.10% (P = 0.009) and absolute
risk reduction (ARR) in overall OHSS incidence = 13.9% at 95%CI of 3.38–24.10 and relative risk (RR) =
0.5 at 95% CI of 0.29–0.85 (p = 0.012) and relative risk reduction (RRR) = 50% and number need to treatment
(NNT) (Benefit) = 7.18 at 95% CI of 4.12 (Benefit) to 28.05 (Benefit)]. Also the incidence of Moderate
OHSS was significantly lower in CIG than OCG [2/115 (1.7 %) vs 10/115 (8.6%), p = 0.01] as well as RR of
severe OHSS with CI to OC = 0.25 at 95%CI of 0.02–2.20 and RRR of severe OHSS with CI to OC was 75% as
it occurred in 4 cases (3.4%) in OCG versus one case (0.8%) in CIG, where this reduction is of great clinical
significant despite it does not reach statistical significance (P = 0.17), at NNT (Benefit) = 38.33 at 95% CI of
87.292 (Harm) to 1