Benha M. J. Vol.8 No 3. Sept. 1991 PLASMA FIBRONECTIN LEVEL IN PATIENTS WITH CHRONIC RENAL FAILURE UNDERGOING REGULAR HEMODIALYSIS : STUDY OF ITS RELATION WITH PROTEIN NUTRITIONAL STATUS AND HEMOSTASIS Maha S. Youssef MD*, Mohamed Shawky MD. El-Metwally El - Shahawy MD, Enas S. El-Shaarrawy MD*, Amal El-Mahdy MD*, Nabil A. Khattab MD, Yehia Saddik MD and Mohamed Salem MD. Department of clinical pathology* and internal medicine**. Benha Faculty of Medicine. Egypt. Abstract Thirty patients with chronic renal failure (10 on conservative measures and 20 on regu¬lar hcmodialysis) and 10 well-matched healthy volunteers comprised the subjects of our study. All of them were subjected to a thorough history taking, clinical examination, an-thropometric measurements to assess the nutritional status and the following laboratory in¬vestigations : Plasma fibronectin level, scrum creatinine, scrum urea, serum albumin, BT, PT, PC. PTT & FDPs Our work showced that CRF significantly decreased plasma FN level, but hemodialysis had no significant effect on it. It was evident that CRF had a significant impact on the nu¬tritional status and the abnormal protein metabolism could explain at least partly the low plasma FN level in urcmic patients. We also found that both renal failure and hcmodialysis had a significant effect on hemostasis and the low plasma FN may be a factor resporsible for banormal hemostasis in urcmic patients . vative