Staff Members - Benha University
STUDY OF SOME PULOMNARY ALTERATIONS IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION
• 2014
Publication Information
Authors
Entesar ELSharqawy MD*, Abeer M. Rawy MD, Mohammad EL Mahdl MD and Usama T.
Galal MD
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background/aim: Chronic hepatitis C virus infection (CHC) has been reported in association
with several extrahepatic manifestations, including pulmonary abnormalities. The aim of this
study was to eluci date the association of CHC with interstitial pulmonary involvement and
its impact on pulmonary functional and radiological changes. Also to evaluate the CHC
effect on pulmonary function tests (PFTs) of pa tients with chronic obstructive pulmonary
disease (COPD) or bronchial asthma. Patients/Methods: Hundred patients were divided into
3 groups, (GI): Thirty patients proved to be CHCt for each patient PFTs, liver biopsy & highresolution CT (HRCT) of chest were done, and its scores were calculated. (G2): Forty
patients with COPD were subdi vided into 4 subgroups (10 for each), (A & B): HCV-ve nonand
current-smokers, (C & D): HCV+ve non- and current-smokers, respectively. For each
patient Forced expiratory volume in the first second (FEV1) and Diffusion capacity of the
lung for carbon monoxide (DLco) were followed up for 3 years. (G3): Thirty patients with
bronchial asthma (17 HCV-ve and 13 HCV+ve), FEV1 was measured before and after
bron-chodilator (salbutamol) and followed up for 3 years. Results: G 1: Ab normal
ventilatory functions and HRCT positive finding were found in 10(33.3%) and 17(56.7%)
of cases respectively. There was significant correlation for
Metavir stage (F) with FEV1/FVC (Forced vital capacity) & HRCT
score (p value
with several extrahepatic manifestations, including pulmonary abnormalities. The aim of this
study was to eluci date the association of CHC with interstitial pulmonary involvement and
its impact on pulmonary functional and radiological changes. Also to evaluate the CHC
effect on pulmonary function tests (PFTs) of pa tients with chronic obstructive pulmonary
disease (COPD) or bronchial asthma. Patients/Methods: Hundred patients were divided into
3 groups, (GI): Thirty patients proved to be CHCt for each patient PFTs, liver biopsy & highresolution CT (HRCT) of chest were done, and its scores were calculated. (G2): Forty
patients with COPD were subdi vided into 4 subgroups (10 for each), (A & B): HCV-ve nonand
current-smokers, (C & D): HCV+ve non- and current-smokers, respectively. For each
patient Forced expiratory volume in the first second (FEV1) and Diffusion capacity of the
lung for carbon monoxide (DLco) were followed up for 3 years. (G3): Thirty patients with
bronchial asthma (17 HCV-ve and 13 HCV+ve), FEV1 was measured before and after
bron-chodilator (salbutamol) and followed up for 3 years. Results: G 1: Ab normal
ventilatory functions and HRCT positive finding were found in 10(33.3%) and 17(56.7%)
of cases respectively. There was significant correlation for
Metavir stage (F) with FEV1/FVC (Forced vital capacity) & HRCT
score (p value