Staff Members - Benha University
Study of serum Granzyme B in heavy cigarette smokers with and without chronic obstructive pulmonary disease
• 2014
Publication Information
Authors
Ahmed A. Yousef a,b, Mahmoud M. Alsalahy a, Mohammad A. Almahdy a,
Tarek S. Essawy a,*, Khalid M. Belal
Keywords
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Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
Open Link
Supplementary Materials
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Abstract
Background: Inflammation of the airways is present in COPD with increased number of
inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis
in which secreted molecules such as granzymes form pores in the membrane of target cells; and
apoptosis. Granzyme B has the strongest apoptotic activity of all granzymes.
Aim of this work: Aim of this work was to study the relation between Granzyme B, tobacco
smoking and chronic obstructive pulmonary disease.
Methods: The study included 40 clinically stable COPD patients classified according to GOLD
(2013) criteria into two groups; moderate (GOLD II) and severe (GOLD III) plus 40 apparently
healthy control subjects (20 smokers and 20 nonsmokers). Pulmonary function results and serum
levels of Granzyme B (measured by ELISA) were recorded.
Results: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD.
Conclusion: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD
inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis
in which secreted molecules such as granzymes form pores in the membrane of target cells; and
apoptosis. Granzyme B has the strongest apoptotic activity of all granzymes.
Aim of this work: Aim of this work was to study the relation between Granzyme B, tobacco
smoking and chronic obstructive pulmonary disease.
Methods: The study included 40 clinically stable COPD patients classified according to GOLD
(2013) criteria into two groups; moderate (GOLD II) and severe (GOLD III) plus 40 apparently
healthy control subjects (20 smokers and 20 nonsmokers). Pulmonary function results and serum
levels of Granzyme B (measured by ELISA) were recorded.
Results: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD.
Conclusion: Granzyme B levels are elevated in COPD. Cigarette smoking appears to be a direct
stimulus to Granzyme B production. Granzyme B could play a role in the pathogenesis of COPD.
Aging seems to be a risk factor for Granzyme B production and pathogenesis of COPD