The increase in life expectancy with therapeutic improvements and age related increasing incidence of ischemic and valvular heart diseases lead to greater number of patients with advanced age who presents for combined coronary and valve operations. Objective The aim of this study is to evaluate the effect of age on survival of patients over 75 years undergoing combined coronary and valve surgery, and to determine the independent risk factors which may predicts survival in those patients. Methods Data was collected prospectively from 476 patients who underwent combined procedures at King's College Hospital, London, UK, between 2004 and 2009. Patients were divided into two groups, group A: 341 patients under the age of 75 years, and group B: 136 above age of 75 years. In-hospital mortality was used for survival analysis. Statistical analysis was performed using SPSS 16. Results The mean age for the entire population is 71 years (range 26-88 years), the mean age for group A is 66 years and is 79 years for group B. 326(68%) patients were male. In addition to the coronary grafting, 339(71%) patients had operation on aortic valve, 132(27.7%) on the mitral valve, 5(1%) on both valves and 1(0.2%) on the tricuspid valve. The following were identified as independent predictors of mortality; female sex (OR 3.191, CI 1.12-8.59, P= 0.022), emergency surgery (OR 3.465, CI 2.73-4.48, P