| publication name | Effects of Triclocarban on Intact Immature Male Rat: Augmentation of Androgen Action |
|---|---|
| Authors | Antoni J. Duleba, MD1, Mohamed I. Ahmed, MD2, Meng Sun, PhD3, Allen C. Gao, MD, PhD3, Jesus Villanueva, DVM, PhD1, Alan J. Conley, DVM, PhD4, Judith L. Turgeon, PhD5, Kurt Benirschke, MD6, Nancy A. Gee, BS7, Jiangang Chen, PhD7, Peter G. Green, PhD8, |
| year | 2011 |
| keywords | triclocarban, androgen receptor, luteinizing hormone, testosterone, endocrine-disrupting substance |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Triclocarban (TCC; 3,4,40-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on human prostate LNCaP and C4–2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplemented with TCC (0.25% in diet) for 10 days. Triclocarban induced hyperplasia of accessory sex organs in the absence of significant qualitative histological changes. Serum luteinizing hormone (LH) and testosterone were not significantly altered by TCC treatment. In prostate cancer-derived LNCaP and C4–2B cells, TCC potentiated androgen actions via androgen receptordependent actions. In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells.