Background:Contrast-induced nephropathy, often known as CIN, is a frequent complication that may occur after procedures that include contrast media administration. Several riskshave been recognized as being independent predictors of CIN; nevertheless, to this day, there are no conclusive data available on the association between the angiographic technique and its development. Aim and objectives:to investigate the incidence of CIN and the variables that may have contributed to its development in patients who had percutaneous coronary intervention (PCI) using either the transfemoral (TF) or the transradial (TR) access technique. Subjects and methods:The Cardiology Departments of Agoza, Benha university, and Benha teachinghospitals participated in this prospective research. Patients who had PCIwere included in the study. Patients with congenital or structural heart disease and people with end-stage renal disease were not included in the study. Patients were categorized into two study groups TFA and TRA. For CIN, it was defined as an absolute (≥0.5 mg/dL) or relative (>25%) increase in the baseline serum creatinine level within 48 hours following PCI. Result:The TFA group showed a significantly higher rate of post-procedural CIN than the TRA group (22 percent vs 6 percent; P =0.041).Also, Contrast volume was significantly higher in the TFA than in the TRA group (P-value