Staff Members - Benha University
TOXICOLOGICAL EFFECT OF COPPER SULPHATE AND COBALT CHLORIDE AS FEED ADDITIVES ON FERTILITY IN MALE ALBINO RATS
• 2014
Publication Information
Authors
Saida A Mohamed, HH Bakry, ME Abou Salem, Nabila A M, Elham A E
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publication.type
Local
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Abstract
This study is designed to investigate the effect of copper sulphate and cobalt chloride, which are used
as additives in feed on fertility of male white albino rats. One hundred rats classified to five groups.
First group used as control; second and third group were given 1/10 and 1/5 LD50 of CuSo4 respectively,
fourth and fifth groups were given 1/10 and 1/5 LD50 of CoCl2 respectively (orally via stomach tube).
Testis and epididymis were dissected and used for detection of sperm motility and counts.
Histopathological examination was performed on testis. Results showed significant decrease in testis
and epididymis weight and significant increase on sperm abnormalities while sperm numbers were
significantly decreased. It can be concluded that ingestion of copper sulphate and cobalt chloride in high
doses decrease fertility in male albino rats.
Key words: cobalt toxicity- copper toxicity – spermatogenesis- heavy metals.
as additives in feed on fertility of male white albino rats. One hundred rats classified to five groups.
First group used as control; second and third group were given 1/10 and 1/5 LD50 of CuSo4 respectively,
fourth and fifth groups were given 1/10 and 1/5 LD50 of CoCl2 respectively (orally via stomach tube).
Testis and epididymis were dissected and used for detection of sperm motility and counts.
Histopathological examination was performed on testis. Results showed significant decrease in testis
and epididymis weight and significant increase on sperm abnormalities while sperm numbers were
significantly decreased. It can be concluded that ingestion of copper sulphate and cobalt chloride in high
doses decrease fertility in male albino rats.
Key words: cobalt toxicity- copper toxicity – spermatogenesis- heavy metals.