Ganadexil@ (enrofloxacin 10 % oral solution ) is a newly pharmaceutical preparation used in poultry industry for treatment of many diseases like colibacillosis, salmonelosis and infections caused by Mycoplasma. The activity of this drug was studied against E.coll, Salmonella gallinarum pullarum and Mycoplasma gallisepticum where the minimum inhibitory concentration was recorded for each pathogen. Another study was performed on poultry with the aim of studying the effect of this drug on antibody titer against Newcastle disease virus. The possible side effect and toxopathological alteration due to enrofloxacine was recorded ,Also the effect of enrofloxacine on the performance and tissue residues were investigated