Nutritional Muscular Dystrophy (NMD) is a disease of lambs results from a selenium and/or vitamin E deficiency. This study was applied on 20 NMD lambs and 20 control native breed lambs from Qalyubia Governorate, with ages ranged from 1 to 4 months, in order to explore the effects of nutritional muscular dystrophy on clinical and hematobiochemical changes in lambs. Affected lambs showed sternal recumbency, stiffness, trembling and muscle tremors, hard swollen muscle and the lamb adopted lateral recumbency . The diseased lamb had significant (P