This work introduces a field study for the performance of a photovoltaic (PV) module under cooling with pure water or -Al2O3/water nanofluid with different nanoparticles volume concentrations (0  φ  1%) flows in straight or helical aluminium channels beneath the PV cell. The results showed that employing the helical channels configuration supplies the highest exergy efficiency along with the uppermost rise in the PV-electrical power. The average increases in the electrical output power are 21.8% and 27.9% when using the straight and helical channels, respectively. Additionally, increasing the nanoparticles fraction in the studied range and the cooling medium flow rate can augment the exergy efficiency. Compared with the standalone cell, the exergy efficiency increases at flow rate of 1 L/min by 76.4% at φ = 1% with increasing the nanoparticles concentration from 0 to 1% for using the helical channels.