OBJECTIVE: To study the histopathological effects of silicone rubber on the human fallopian tube. METHODS: A prospective longitudinal study at BenhaUniversit Hospital and Boulak Eldakror General Hospital, Egypt. Nine patients who were in the waiting list for hysterectomy and requested postoning of their operation for personal reasons. RESULTS: Our results suggest that silicone rubber induces histopathological changes in the form of ciliary loss and intracellular changes. CONCLUSIONS: These effects end to increase with the increase of the duration of tubal plugging and are best seen by electron microscopy.