Sahl El-Hussainia is an important reclamation project in Egypt located on El-Salam channel. Soils of these areas are irrigated with drainage water mixed with Nile water at a ratio of 1:1. North of Sahl El- Hussinia there exists Lake Manzalla, which receives large quantities of domestic, industrial, and agricultural discharges. The current study was aimed at measuring the contamination level of Sahl El-Hussainia soils with heavy metals and their effects on the grown plant contents of these contaminants. In addition, human risks resulting due to exposure to these heavy metals through different exposure routes were evaluated. To achieve these goals, soil and rice plant samples were collected from Khalid Ibn El-Waleed village, SahlEl- Hussainia, and analyzed for their contents of trace elements, i.e. Pb, Cd, Co, Ni, As, and Se. The results reveal that the soil of study suffers from moderate contamination with Pb, Co, Ni, and As to severe contamination with Cd and Se. Moreover, As and Pb were found at high concentrations in rice grains exceeding the permissible ones. The expected health risk assessments indicate that As, Se, and Pb can possess a health threat for children, whereas only As and Se can posses health problem for adults. Arsenic was found to contribute to more magnitude of cancer risks. Finally, bad management of Sahl El-Hussainia resulted in contamination of soil with trace elements. Accordingly, food obtained from the area of study might not be suitable for human consumption.