In this paper, the effect of convective boundary conditions, heat generation, Brownian motion, and thermophoresis on heat transfer characteristics of a moving cylinder embedded into cooling medium consists of water with nanoparticles are studied. The governing boundary-layer equations transformed to ODE using similarity transformation method and then solved analytically using optimal homotopy asymptotic method for the general case. The velocity, temperature, and concentration profiles within the boundary-layer plotted and discussed in details for various values of the different parameters. Moreover, the effect of boundary-layer behavior on the surface shear stress, rate of heat and mass transfer investigated.