This work investigate the thermal diffusion and diffusion thermo effects on mixed convection heat and mass transfer by MHD stagnation point flow towards permeable stretching surface in the presence of a first order chemical reaction by using numerical method .The governing equations are transformed into a system of nonlinear ordinary differential equations by using similarity transformation which are then solved numerically using fourth order Runge-Kutt method with shooting technique. A detailed study illustrating the influences of the effects of the magnetic, Dufour, Soret, velocity ratio, suction/injection and chemical reaction parameters, the Schmidt and Prandtl numbers on the dimensionless velocity, temperature as well as the skin-friction and the Nusselt and Sherwood numbers is conducted. The results obtained show that the flow field is substantially influenced by the presence of chemical reaction, transpiration, thermal diffusion and diffusion thermo, and magnetic field.