The effects of thermal radiation, heat generation, chemical reaction and suction/injection on heat and mass transfer characteristics over a stretching surface subjected to three dimensional flow are studied. The governing boundary layer equations are transformed to ordinary differential equations containing thermal radiation parameter, heat generation parameter,suction/injection parameter, stretching ratio parameter, chemical reaction parameter, prandtl and Schmidt number. These equations are solved through applying symbolic computation to Runge-Kutta technique in order to solve four point boundary value problem. The velocity, temperature and concentration profiles are plotted and discussed in details for various values of the different embedded flow parameters.