The air conditioning systems of low humidity applications consume huge amount of energy to maintain the required low temperature and humidity needed by the application. In the present work, proposed efficient systems that integrate the technologies of desiccant dehumidification, evaporative cooling, and fresh water production with the air conditioning system of low-humidity applications are presented. Thermodynamics analysis of the systems is conducted and the systems of equations are analytically solved and analyzed using EES and mat lab software. Parametric studies are conducted to investigate the effects of the different operating parameters on the systems performance. The power savings and the fresh water productions of the different proposed systems are evaluated and compared to select the optimum system configuration.