Background :Diabetic peripheral neuropathy (DPN) is a diabetes
mellitus (DM) induced disorder of the peripheral nervous system and
is characterized by pain and loss of sensation due to symmetrical
degeneration of distal peripheral nerves.Studies have shown that
magnesium levels are lower in patients with diabetes compared with
nondiabetic controls.
Objective: to study plasma magnesium status in type 2 diabetic
patients with and without diabetic neuropathy .
Subjects and Methods; A sample of 110 subjects were included
and devided into: group (I) ; including 10 patients without diabetes as
control ,group(II)including 74 patients of type 2 diabetic with
clinically evident neuropathy ; group (III); including 26 patients of
type2 diabetics without clinically evident neuropathy .All patients
subjected to detailed medical history , complete clinical examination ,
fundoscopic examination , laboratory investigations including; RBS;
plasma magnesium Levels , HbA1C,Urine analysis, 24 hrs. urinary
albumin, estimated GFR., excluding patients with renal faluire , acute
myocardial infarction , patients on diuretics, aminoglycosides and
other drugs causing magnesium supplements and magnesium
containing antacids , pregnant and lactating women.
Results: the comparative study consists of 10 patients without
diabetes as control(groupI), 74 patients of type 2 diabetes with
clinically evident neuropathy (groupII) , 26 patients of type 2
diabetes without clinically evident neuropathy.the avaeage range of
plasma magnesium level among 3 groups was 2.12±0.15, 1.47±0.30 ,
1.93±0.26 respectively , there is asignificantly statistical difference
among the three groups (p