Late Cretaceous (Campanian-Maastrichtian) marine actinopterygians from the southern Tethys platform are underreported and understudied in comparison to chondrichthyans from this region. Exposures of the Duwi Formation near the Dakhla, Kharga and Baris oases preserve a diverse assortment of actinopterygian fishes not previously reported from this unit. Horizons yielding fossils represent shallow marine deposits of upper Campanian-lower Maastrichtian age. The actinopterygian assemblage includes representatives of several groups of largebodied, predatory fishes, all of which belong to the teleost total group: †Pachycormiformes (†Pachycormidae), †Pachyrhizodontiformes (†Pachyrhizodontidae), †Ichthyodectiformes (†Saurodontidae), and Aulopiformes (†Enchodontidae, † Dercetidae and †Cimolichthyidae). The presence of saurodontids in the Duwi Formation is noteworthy as the first confidently identified fossils for this group from Africa. Specimens are based on and diagnosed from isolated and fragmentary elements, implying significant disarticulation prior to burial. Palaeobiogeographically, actinopterygians of the Duwi Formation show compositional similarity with assemblages from the Northern Tethys Platform and the Western Interior Seaway of North America, consistent with mounting evidence for communication across the Tethys Ocean. Additional exploration of the uppermost Cretaceous units in southern Egypt promises potential for the discovery of important fossils to better characterize the composition and paleogeographic distribution of the latest Cretaceous ichthyofauna of the Tethys region.