The influence of three compounds of anti-ulcer prazole drugs on the dissolution of aluminum electrode in 1.0M HCl solution was investigated using weight loss, hydrogen evolution reaction, galvanostatic polarization and electrochemical impedance spectroscopy techniques .The inhibition efficiency was found to increase with increasing the concentration of the inhibitors and with decreasing the temperature. The inhibition action of these compounds was explained in terms of adsorption on the aluminum surface. The adsorption process follows Langmuir isotherm .Some activated thermodynamic parameters were calculated. The polarization studies showed that these compounds are acting as mixed inhibitors. Electrochemical impedance spectroscopy technique exhibit one capacitive loop indicating that, the corrosion reaction is controlled by charge transfer process. The results obtained from different techniques are in good agreement.