The present study aimed to investigate the impact of feeding soft white cheese containing vegetable oils and made with the use of some starter cultures on some cardiovascular parameters of rats. The experimental procedure included 36 female albino rats fed on basal diet for one week and then divided into 6 groups; two of them were positive and negative controls. The other four groups were fed for 6 weeks on the above mentioned cheese. The results indicated that the non-traditional white soft cheeses were more effective in lowering serum total cholesterol especially T3 (3% starter culture). The serum triglycerides level, serum VLDL + LDL level, The TC/HDL and LDL/HDL ratios were decreased. All the blood serum HDL cholesterol were also, gradually decreased. Serum glutamic oxaloacetic transaminase (GOT) level, showed a significantly low activity whereas, T3 was the lowest. On the other hand, the serum glutamic pyrovic transaminase (GPT) levels were observed to have a significant decrease in the serum levels of this enzyme relative to the negative control treated group. Hence, the non-traditional white soft cheese made with vegetable oils and starter culture could be better protecting against coronary heart disease