The present work was done on the health promoting power for lowering the blood cholesterol by feeding the rate on advanced non-traditional soft white cheese with vegetable oils and starter cultures. The experimental included 36 female albino rates fed on basal diet for one week and then divided into 6 groups two of them were served as positive and negative controls, The other 4 groups were fed for 6 weeks on the above mentioned cheese treatments. The non-traditional white soft cheeses were more effective in lowering serum total cholesterol especially T3 (3% starter culture). The serum triglycerides level, serum VLDL + LDL level, The TC/HDL and LDL/HDL ratios were showed a pronounced decrease as the time of feeding progressed. All the blood serum HDL cholesterol were also gradually decreased. Serum glutamic oxalacetic transaminase (GOT) level showed a significantly low activity whereas, T3 was the lowest. On the other hand the serum glutamic pyrovatic transaninase (GPT) level were observed to have a significant decrease in the serum levels of this enzymes relative to the negative control treated group. Hence the non-traditional white soft cheese made with vegetable oils and starter culture copuld be better protect against coronary heart disease.