Background: A pandemic of Coronavirus 2019 (COVID-19)may endanger the mental well-being of health care workers. Objective: This is to stipulate some mental issues faced by health care workers at the time of COV-SARS. Patients and Method: A cross-sectional study was conducted upon 5745 participants from the Qalyubiya Governorate (7 centers). Online self-administered questionnaire (Fear of Coronavirus-19 Scale (7 Qs scale) and The Hospital Anxiety and Depression Scale (HADS) (14 items of two subscales: anxiety and depression)) was utilized. Propensity score matching was performed to minimize bias between health care workers (1740) and non-healthcare workers. Results: After performing propensity score matching, 1740 participants were included for comparison between health care workers and non-healthcare workers. Health care workers expressed more fear, anxiety, and depression scores. Increasing hours of watching media is a predictor of fear, anxiety, and depression among health care workers ((95%CI: 0.555-1.4, p