Female pattern hair loss, or FPHL, is a disorder that affects millions of women worldwide and may be emotionally and psychologically taxing in addition to being visually disconcerting. A successful result can only be achieved with a timely diagnosis and treatment. Diffuse thinning of hair on the crown and front of the scalp, with the hairline remaining unaffected, characterises female pattern hair loss (FPHL), the most frequent kind of hair loss in women. It becomes more common as people become older and is linked to serious mental health issues. It seems that there are several factors involved in FPHL's pathogenesis, which remains poorly understood. Although androgens have been suspected, the absence of clinical or biochemical indicators of hyperandrogenism in afflicted women suggests that other, androgen-independent processes are at play. Increasing evidence suggests that genetic variants affecting the androgen and oestrogen receptors have a significant role in both its aetiology and the ability to predict response to anti-androgen therapy. The purpose of this research was to examine whether or not FPHL is associated with single-nucleotide polymorphisms (SNPs) in the CYP19A1 gene among Egyptian women.